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Literature summary extracted from

  • Wu, S.; Wang, Y.; Lin, L.; Si, X.; Wang, T.; Zhong, X.; Tong, L.; Luan, Y.; Chen, Y.; Li, X.; Zhang, F.; Zhao, W.; Zhong, Z.
    Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections (2015), Virol. J., 11, 192.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.29 D136N the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
3.4.22.29 D136N the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
3.4.22.29 D39E the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
3.4.22.29 D39E the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
3.4.22.29 G122E the mutant exhibits very low cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
3.4.22.29 G122E the mutant exhibits very low cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
3.4.22.29 L40F the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
3.4.22.29 L40F the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
3.4.22.29 S67F the mutant shows reduced cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
3.4.22.29 S67F the mutant shows reduced cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
3.4.22.29 V120M the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
3.4.22.29 V120M the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
3.4.22.29 Y89L the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
3.4.22.29 Y89L the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
3.4.22.29 Y90L the mutant shows reduced cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
3.4.22.29 Y90L the mutant shows reduced cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.29 eukaryotic initiation factor 4G + H2O Coxsackievirus B3
-
 ?
-
 ?
3.4.22.29 eukaryotic initiation factor 4G + H2O Enterovirus A71
-
 ?
-
 ?
3.4.22.29 eukaryotic initiation factor 4G + H2O Coxsackievirus B3 Woodruff
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.29 Coxsackievirus B3 Q66282
-
-
3.4.22.29 Coxsackievirus B3 Woodruff Q66282
-
-
3.4.22.29 Enterovirus A71 Q66478
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.29 eukaryotic initiation factor 4G + H2O
-
 Coxsackievirus B3 ?
-
 ?
3.4.22.29 eukaryotic initiation factor 4G + H2O
-
 Enterovirus A71 ?
-
 ?
3.4.22.29 eukaryotic initiation factor 4G + H2O
-
 Coxsackievirus B3 Woodruff ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.29 2A protease
-
 Coxsackievirus B3
3.4.22.29 2A protease
-
 Enterovirus A71
3.4.22.29 2Apro
-
 Coxsackievirus B3
3.4.22.29 2Apro
-
 Enterovirus A71

General Information

EC Number General Information Comment Organism
3.4.22.29 physiological function 2A protease is the key viral component that triggers stress granule formation Coxsackievirus B3
3.4.22.29 physiological function 2A protease is the key viral component that triggers stress granule formation Enterovirus A71